This method implements an idea similar to print-tip loess
normalisation but uses regression splines in place of the loess
curves and uses empirical Bayes ideas to shrink the individual
print-tip curves towards a common value. This allows the technique
to introduce less noise into good quality arrays with little
spatial variation while still giving good results on arrays with
strong spatial variation [4].
Bjørn Kåre Alsberg
2006-04-06